General Info

Ulivieri Cristina - Assistant Professor/Ricercatore

Email: ulivieri@unisi.it

Office/Ufficio: +39 (0)577 234403

Laboratory/Laboratorio: +39 (0)577 234396

Fax: +39 (0)577 234476

Skype: -

Research Group

Nico Giommoni, Nagaja Capitani, Orso Maria Lucherini, Cosima Tatiana Baldari, Silvia Rossi Paccani, Francesca Finetti, Laura Patrussi, Giulia Masi, Cristina Ulivieri, Daniela Fanigliulo, Maria Teresa Savino, Micol Ferro

Research Interest

Current research topics include:

Molecular characterization of the TCR and FceRI pathways, with a focus on the Shc adaptor protein family

Dysregulation of TCR and FceRI pathways in autoimmune diseases

Immunomodulation through targeting TCR signaling

Curriculum Vitae

Name Cristina Ulivieri

Place and date of birth Vinci (Firenze) 11-03-1970

University Education

1996 Degree with honours in Biological Sciences, Faculty of Mathematical, Physical and Natural Sciences,   University of Siena. Experimental thesis in Molecular Biology under the supervision of Prof. Cosima T. Baldari and J.L. Telford -Department of Molecular Biology, Chiron Vaccines, Siena.

2001 Master in Evolutionary Biology, University of Siena.

2004 PhD in Evolutionary Biology, University of Siena.

Attendance to pratical courses

2000 Pratical course of flow cytometry -Becton Dickinson, Milano, Italy

2002 SICiCS Workshop on cytometry –I.R.C.C.S. Roma, Italy

One-day-Symposio” Optical microscopy: Old principles and new probes”-Univ. Ferrara, Italy

2003 Confocal microscopy and application -Leica Microsystem, Siena, Italy

2007 IV Interactive Course in Cytometry -SIICA, Modena, Italy

Current position

Assistant Professor of Molecular Biology -Dept. Evolutionary Biology, Univ. Siena

Previous position

1996-1997 Post-doctoral research contract -Dept. Evolutionary Biology, University of Siena

1997-1998 Post-doctoral University of Siena fellow -Dept. Evolutionary Biology, University of Siena

7/1999-10/2000 Visiting scientist -The Basel Institute for Immunology (Lab. Ed Palmer), Switzerland.

1999-2001 Post-doctoral FIRC fellow -Dept. of Evolutionary Biology, University of Siena.

Recipient of research funds “Giovani Ricercatori 2001” University of Siena.

2002-2004 Post-doctoral research contract -Dept. Evolutionary Biology, Univ. Siena.

Teaching experience

1997-2003 Pratical course under Prof. C.T. Baldari’s coordination of Experimental Biology II (1997-2001), Experimental Biology II (1999-2003), Molecular biology II (1997-2003).

2002-2004 Contract professor of Genetic manipulation (2002-2003), Electronic Microscopy, Molecular Biology  and Biochemistry laboratory; Recombinant DNA technology (2003-2004).

2003-2009 Contract professor of Molecular Biology Bioinformatic Master “Alberto Del Lungo” Univ. Siena (2003-2008). Assistant Professor of Molecular Biology and Biochemistry laboratory (2005-2009); Recombinant DNA technology (2005-2009) and Molecular Immunology technologies (2006-2008) courses at University of Siena.

Expertise

Experience in the field of antigen receptor and chemokine receptor signaling in lymphocytes, with a focus on the Shc protein family, and dysregulation of these process both by drugs (NSAIDs, Statins) and by bacterila pathogens (H. pylory).

Experience in the field of Flow cytometry and mouse model

Selected Publications

Savino MT, Ortensi B, Ferro M, Ulivieri C, Fanigliulo D, Paccagnini E, Lazzi S, Osti D, Pelicci G, Baldari CT. Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation. J Immunol. 2009 Jan 1;182(1):301-8..

Ulivieri C, Fanigliulo D, Benati D, Pasini FL, Baldari CT. Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation. Eur J Immunol. 2008 Oct;38(10):2832-44.

Ulivieri C, Citro A, Ivaldi F, Mascolo D, Ghittoni R, Fanigliulo D, Manca F, Baldari CT, Li Pira G, Del Pozzo G. Antigenic properties of HCMV peptides displayed by filamentous bacteriophages vs. synthetic peptides. Immunol Lett. 2008 Aug 15;119(1-2):62-70.

Finetti F, Pellegrini M, Ulivieri C, Savino MT, Paccagnini E, Ginanneschi C, Lanfrancone L, Pelicci PG, Baldari CT. The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity. Blood. 2008 May 15;111(10):5017-27.

Pellegrini M, Finetti F, Petronilli V, Ulivieri C, Giusti F, Lupetti P, Giorgio M, Pelicci PG, Bernardi P, Baldari CT. p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis. Cell Death Differ. 2007 Feb;14(2):338-47.

Boncristiano M, Paccani SR, Barone S, Ulivieri C, Patrussi L, Ilver D, Amedei A, D'Elios MM, Telford JL, Baldari CT. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med. 2003 Dec15;198(12):1887-97.

Ulivieri C, Valensin S, Majolini MB, Matthews RJ, Baldari CT. Normal B-1 cell development but defective BCR signaling in Lck-/- mice. Eur J Immunol. 2003 Feb;33(2):441-5.

Ulivieri C, Peter A, Orsini E, Palmer E, Baldari CT. Defective signaling to Fyn by a T cell antigen receptor lacking the alpha -chain connecting peptide motif. J Biol Chem. 2001 Feb 2;276(5):3574-80.

Ulivieri C, Pacini S, Bartalini S, Valensin S, Telford JL, Baldari CT. Obligatory cross-talk with the tyrosine kinases assembled with the TCR/CD3 complex in CD4 signal transduction. Eur J Immunol. 1999 Aug;29(8):2625-35.

Ulivieri C, Burroni D, Telford JL, Baldari CT. Generation of a monoclonal antibody to a defined portion of the Helicobacter pylori vacuolating cytotoxin by DNA immunization. J Biotechnol. 1996 Nov 1;51(2):191-4.