General Info

Finetti Francesca - Post Doc

Email: finetti4@unisi.it

Office/Ufficio: +39 (0)577 2344393

Laboratory/Laboratorio: +39 (0)577 234396

Fax: +39 (0)577 234476

Skype: -

Research Group

Nico Giommoni, Nagaja Capitani, Orso Maria Lucherini, Cosima Tatiana Baldari, Silvia Rossi Paccani, Francesca Finetti, Laura Patrussi, Giulia Masi, Cristina Ulivieri, Daniela Fanigliulo, Maria Teresa Savino, Micol Ferro

Research Interest

The activity of the lab is focused on the functional dissection of signal transduction pathways in lymphocyte activation and apoptosis and dysregulation of these processes un lymphoproliferative, immunodeficiency and pathogen-related diseases.

Current research topics include:

* Characterization of the Shc family of protein adapters in the immune system
* Modulation of antigen receptor signaling by bacterial toxins as a strategy of immune evasion
* Regulation of membrane trafficking at the immune synapse by the intraflagellar transport system

Curriculum Vitae

Name:            Francesca FINETTI
Date of birth:        1 october 1979
Place of birth :          Siena (SI)
Nationality:        Italian
E-mail:            finetti4@unisi.it

UNIVERSITY EDUCATION:

2002         First level doctoral degree with honors in Biological Sciences (17/10/2002), University of Siena, Italy. Experimental thesis work in Molecular Biology. Title: “Biochemical and functional analysis of Shc tyrosines involved in T lymphocytes signaling pathways ”. Supervisor Prof. C. Baldari, Dept. Evolutionary Biology, University of Siena

2004        Second level doctoral degree with honors in Molecular Biology (28/10/2004), University of Siena, Italy. Experimental thesis work in Molecular Biology. Title: “p66Shc, Ca2+ homeostasis and apoptosis in T lymphocytes”. Supervisor Prof. C. Baldari, Dept. Evolutionary Biology, University of Siena

2004-2007        PhD studentship in Evolutionary Biology (from 1/11/2004), Dept. Evolutionary Biology, University of Siena

2005        Master in Evolutionary Biology (20/12/05), Dept. Evolutionary Biology, University of Siena

2008    PhD in Evolutionary Biology, Dept. Evolutionary Biology, University of Siena Experimental thesis work in Molecular Biology (14/03/08). Title: “Impaired lymphocyte homeostasis and systemic autoimmunity in p66Shc-/- mice”.


SCIENTIFIC ACTIVITY:

2008-2009    Post-doctoral AIRC fellowship, Dept. Evolutionary Biology, University of Siena    

Since 2010    Post−doctoral researcher (assegnista di ricerca), Dept. Evolutionary Biology, Univ of Siena

Research Focus:

2004-2008    Molecular and functional characterization of p66Shc protein in T cells. Detection of a novel role for Shc proteins in lymphocyte apoptosis and in negative regulation of lymphocyte activation by demonstration that p66Shc-/- mice spontaneously develop systemic autoimmunity.

Since 2008     Research project on expression and function of intraflagellar transport (IFT) proteins in immune cells. Characterization of IFT20 protein as a new regulator of immune synapse assembly in T cells.



Teaching experience:

2005-2006    Instructor, Course of Experimental Biology I and II. Faculty of Sciences, Univ. Siena
2008-2009    Instructor, Course of “Anatomia e Istologia del topo”. Faculty of Sciences, Univ. Siena

Selected Publications

Silvia Rossi Paccani, Francesca Finetti, Marilyne Davi, Laura Patrussi, Daniel Ladant, Cosima T Baldari. The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its release from the immune synapse (JEM 2010, submitted)

 

Capitani N, Lucherini OM, Sozzi E, Ferro M, Giommoni N, Finetti F, De Falco G, Cencini E, Raspadori D, Pelicci PG, Lauria F, Forconi F, Baldari CT. Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood. 2010 May 6;115(18):3726-36.

 

Finetti F, Savino MT, Baldari CT. Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters. Immunol Rev. 2009 Nov;232(1):115-34.

 

Finetti F, Paccani SR, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum JL, Baldari CT.Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol. 2009 Nov;11(11):1332-9.

 

Tiepolo T, Angelin A, Palma E, Sabatelli P, Merlini L, Nicolosi L, Finetti F, Braghetta P, Vuagniaux G, Dumont JM, Baldari CT, Bonaldo P, Bernardi P. The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice. Br J Pharmacol. 2009 Jul;157(6):1045-52.

 

Finetti F, Pellegrini M, Ulivieri C, Savino MT, Paccagnini E, Ginanneschi C, Lanfrancone L, Pelicci PG, Baldari CT. “The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity”. Blood, 2008 May 15;111(10):5017-27.

 

Pellegrini M., Finetti F., Petronilli V., Ulivieri C., Giusti F., Lupetti P., Giorgio M., Pelicci PG. Bernardi P. and Baldari CT. “p66Shc promotes T-cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis”. Cell Death and Differentiation, 2007 Feb;14(2):338-47.

 

Spiga O., Bernini A., Ciutti A., Chiellini S., Menciassi N., Finetti F., Causarono V., Anselmi F., Prischi F. and Niccolai N. “Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein”. Biochemical and Biophysical Research Communications, 310, 78–83 (2003).