General Info

Patrussi Laura - Post Doc

Email: patrussi2@unisi.it

Office/Ufficio: +39 (0)577 234393

Laboratory/Laboratorio: +39 (0)577 234396

Fax: +39 (0)577 234476

Skype: -

Research Group

Nico Giommoni, Nagaja Capitani, Orso Maria Lucherini, Cosima Tatiana Baldari, Silvia Rossi Paccani, Francesca Finetti, Laura Patrussi, Giulia Masi, Cristina Ulivieri, Daniela Fanigliulo, Maria Teresa Savino, Micol Ferro

Curriculum Vitae

Name:             Laura PATRUSSI
Date of Birth:   September 11, 1975
Place of Birth:   Arezzo (AR)
Country:           Italy
Phone:            (39) (0575) 440148 / (39) (0577) 234396
Fax:                (39) (0577) 234476
E-mail:            patrussi2@unisi.it

Education
1994            High school degree, Liceo Classico Statale “F. Petrarca”, Arezzo, Italy

1994-2001    Doctoral graduation with honors in Biological Sciences, University of Siena, Italy
2000-2001    Experimental thesis work in Molecular Biology, Supervisor Prof. C. Baldari Dept. Evolutionary Biology, University of Siena

2002            Master in Evolutionary Biology, Dept. Evolutionary Biology, University of Siena
2001-2004    PhD studentship in Evolutionary Biology, Dept. Evolutionary Biology, University of Siena
2005            PhD in Evolutionary Biology, Dept. Evolutionary Biology, University of Siena

Scientific activity
1/2006         Postdoctoral fellowship, Dept. Evolutionary Biology, University of Siena
6/2006         Postdoctoral Researcher (Assegno di Ricerca), Dept. Evolutionary Biology, University of Siena
Since 2001    Staff scientist, Dept. Evolutionary Biology, University of Siena

Main research focus
2001-2004    Molecular and functional characterization of p52Shc protein in T cells.
2004-2008    Detection of a novel role of p52Shc in chemotaxis of T cells
2008-2010    Biochemical dissection of p66Shc-dependent apoptosis in T cells

Teaching experience
2000-2001    Instructor, course of Experimental Biology I and II, Faculty of Sciences, University of Siena
Supervisor of the experimental thesis work of three graduate students
2006-2007    Instructor, course of Experimental Biology, Faculty of Sciences, University of Siena
2009-2010    Instructor, course of Molecular Biology, Speciality school of Medical Genetics, University of  Siena
2009-2010    Instructor, course of Molecular Biology, Speciality school of Pathological Anatomy, University of Siena

Selected Publications

PATRUSSI L. and C.T. BALDARI. Positive and negative regulators of Ras in T cells (Review). (2004) Signal Transduction, 1-2; 9-16.

PACCANI SR, PATRUSSI L, ULIVIERI C, MASFERRER JL, D'ELIOS MM, BALDARI CT. Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signalling. Blood. 2005 Mar 1;105(5):2042-8. Epub 2004 Oct 28.

ROSSI PACCANI, S., BONCRISTIANO, M., PATRUSSI, L., ULIVIERI, C., VALENSIN, S., HIRST, T.R., DEL PRETE, G., TELFORD, J.L., D’ELIOS, M.M. and BALDARI, C.T. Detective Vav expression and impaired F-actin reorganization in a subset of common variable immunodeficiency patients with T-cell defects. Blood. 2005 Jul 15;106(2):626-34.

PATRUSSI, L., SAVINO, M.T., PELLEGRINI, M., ROSSI PACCANI, S., MIGLIACCIO, E., PLYTE, S., LANFRANCONE, L., PELICCI, P.G., and C.T. BALDARI. Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T cell antigen receptor signaling to Ras family GTPases and Myc dependent survival pathway. Oncogene. 2005 Mar 24;24(13):2218-28.

GHITTONI R., L. PATRUSSI, K. PIROZZI, P.E. LAZZERINI, P.L. CAPECCHI, F. LAGHI-PASINI and C.T. BALDARI. Simvastatin inhibits T cell activation by selectively impairing  the function  of Ras superfamily GTPases. FASEB J. 2005 Apr;19(6):605-7.

GHITTONI R., NAPOLITANI G., BENATI D., ULIVIERI C., PATRUSSI L., LAGHI PASINI F., LANZAVECCHIA A. and C.T. BALDARI. Simvastatin inhibits the MHCII pathway of antigen processing and presentation by impairing Ras superfamily GTPase dependent antigen uptake. Eur J Immunol. 2006 Nov;36(11):2885-93. Erratum in: Eur J Immunol. 2006 Dec;36(12):3381.

ROSSI PACCANI, S., TONELLO, F., PATRUSSI, L., CAPITANI, N., SIMONATO, M., MONTECUCCO, C. and C.T. BALDARI. anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signaling. Cell Microbiol. 2007 Apr;9(4):924-9. Epub 2006 Nov 3.

PATRUSSI, L., ULIVIERI, C., LUCHERINI, O.M., PACCANI, S.R., GAMBERUCCI, A., LANFRANCONE, L., PELICCI, P.G., BALDARI, C.T. p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells. Blood. 2007 Sep 15;110(6):1730-8. Epub 2007 May 30.

PATRUSSI, L., MARIGGIO', S., PACCANI, S.R., CAPITANI, N., ZIZZA, P., CORDA, D., BALDARI, C.T. Glycerophosphoinositol-4-phosphate enhances SDF-1alpha-stimulated T-cell chemotaxis through PTK-dependent activation of Vav. Cell Signal. 2007 Nov;19(11):2351-60. Epub 2007 Jul 28.

PATRUSSI, L. AND BALDARI, C.T. Intracellular mediators of CXCR4 signaling in T cells. Review. Immunology Letters 2008 Jan 29;115(2):75-82. Epub 2007 Nov 20.

PATRUSSI, L. AND BALDARI, C.T. The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection. Review. Current Medicinal Chemistry, in press.